Are Last Drop™ Inlet Filters Suitable for UHPLC Systems?

Yes. MICROSOLV Last Drop™ Mobile Phase Inlet Filters can be used with UHPLC systems.

Because UHPLC columns utilize smaller particle sizes and higher operating pressures, maintaining clean mobile phases becomes increasingly important. Proper inlet filtration helps reduce the risk of particulate contamination reaching:

• Solvent delivery systems
• Check valves
• Pumps
• Mixers
• Injector components
• UHPLC columns

Recommended Filter Pore Size for UHPLC

For UHPLC columns packed with 3 µm particles or smaller, a 0.2 µm inlet filter is recommended.

Benefits include:

• Improved particulate removal
• Enhanced protection of UHPLC components
• Reduced risk of column blockage
• Improved long-term system reliability

Users should note that smaller pore sizes may slightly reduce fluid flow through the inlet filter compared to larger pore-size alternatives.

View Last Drop™ Mobile Phase Inlet Filter Ordering Information and Product Specifications

Why Mobile Phase Filtration Matters

Proper mobile phase filtration helps:

• Protect pumps and check valves
• Extend column life
• Minimize particulate buildup
• Improve chromatographic reproducibility
• Reduce maintenance requirements

These benefits are particularly important in UHPLC systems where smaller particle columns are more sensitive to contamination.

Key Takeaways

• Last Drop™ Inlet Filters are compatible with UHPLC systems.
• A 0.2 µm inlet filter is recommended for columns packed with 3 µm particles or smaller.
• Smaller pore sizes may result in slower flow through the filter.
• Mobile phase filtration helps protect both UHPLC systems and columns from particulate contamination.